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Target
Fibroblast growth factor receptor 1
Ligand
BDBM50162976
Substrate
n/a
Meas. Tech.
ChEMBL_306384 (CHEMBL828725)
IC50
>10000±n/a nM
Citation
 Baindur, N; Chadha, N; Brandt, BM; Asgari, D; Patch, RJ; Schalk-Hihi, C; Carver, TE; Petrounia, IP; Baumann, CA; Ott, H; Manthey, C; Springer, BA; Player, MR 2-Hydroxy-4,6-diamino-[1,3,5]triazines: a novel class of VEGF-R2 (KDR) tyrosine kinase inhibitors. J Med Chem 48:1717-20 (2005) [PubMed]  Article
Target
Name:
Fibroblast growth factor receptor 1
Synonyms:
FGFR1_MOUSE | Fgfr1 | Fibroblast growth factor receptor | Fibroblast growth factor receptor 1 | Flg
Type:
PROTEIN
Mol. Mass.:
91976.92
Organism:
Mus musculus
Description:
ChEMBL_306384
Residue:
822
Sequence:
MWGWKCLLFWAVLVTATLCTARPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSINWLRDGVQLVESNRTRITGEEVEVRDSIPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMLGSVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSIPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPTQLANSGLKRR
  
Inhibitor
Name:
BDBM50162976
Synonyms:
4-(Benzothiazol-6-ylamino)-6-(1-methyl-1-phenyl-ethylamino)-[1,3,5]triazin-2-ol | CHEMBL175862
Type:
Small organic molecule
Emp. Form.:
C19H18N6OS
Mol. Mass.:
378.451
SMILES:
CC(C)(Nc1nc(Nc2ccc3ncsc3c2)[nH]c(=O)n1)c1ccccc1
Structure:
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