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Target
Protein kinase C alpha type
Ligand
BDBM50591643
Substrate
n/a
Meas. Tech.
ChEMBL_2200954 (CHEMBL5113662)
Ki
4.5±n/a nM
Citation
 Vaidya, GN; Rana, P; Venkatesh, A; Chatterjee, DR; Contractor, D; Satpute, DP; Nagpure, M; Jain, A; Kumar, D Paradigm shift of "classical" HDAC inhibitors to "hybrid" HDAC inhibitors in therapeutic interventions. Eur J Med Chem 209:0 (2021) [PubMed]  Article
Target
Name:
Protein kinase C alpha type
Synonyms:
KPCA_MOUSE | Pkca | Prkca | Protein kinase C | Protein kinase C alpha | Protein kinase C alpha type
Type:
Enzyme Catalytic Domain
Mol. Mass.:
76858.67
Organism:
MOUSE
Description:
Protein kinase C 0 MOUSE::P20444
Residue:
672
Sequence:
MADVYPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINDPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSNLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKAHNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPVGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLNNVMLNSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKQPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
  
Inhibitor
Name:
BDBM50591643
Synonyms:
CHEMBL5172956
Type:
Small organic molecule
Emp. Form.:
C24H38N2O4S
Mol. Mass.:
450.635
SMILES:
CC(C)[C@H]1N(C)c2cc(OCCCCCCCSC(C)=O)ccc2C[C@H](CO)NC1=O |r|
Structure:
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