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Target
Histone deacetylase 8
Ligand
BDBM50526164
Substrate
n/a
Meas. Tech.
ChEMBL_2203382 (CHEMBL5116090)
IC50
1561±n/a nM
Citation
 Pulya, S; Patel, T; Paul, M; Adhikari, N; Banerjee, S; Routholla, G; Biswas, S; Jha, T; Ghosh, B Selective inhibition of histone deacetylase 3 by novel hydrazide based small molecules as therapeutic intervention for the treatment of cancer. Eur J Med Chem 238:0 (2022) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50526164
Synonyms:
CHEMBL4589724
Type:
Small organic molecule
Emp. Form.:
C18H17N5O
Mol. Mass.:
319.3605
SMILES:
Nc1ccccc1NC(=O)c1cnc(NCc2ccccc2)cn1
Structure:
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