Reaction Details  Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50165031
Substrate
n/a
Meas. Tech.
ChEMBL_304127 (CHEMBL840244)
EC50
90±n/a nM
Citation
 McKerrecher, D; Allen, JV; Bowker, SS; Boyd, S; Caulkett, PW; Currie, GS; Davies, CD; Fenwick, ML; Gaskin, H; Grange, E; Hargreaves, RB; Hayter, BR; James, R; Johnson, KM; Johnstone, C; Jones, CD; Lackie, S; Rayner, JW; Walker, RP Discovery, synthesis and biological evaluation of novel glucokinase activators. Bioorg Med Chem Lett 15:2103-6 (2005) [PubMed]  Article
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50165031
Synonyms:
6-({3-isopropoxy-5-[2-(3-thienyl)ethoxy]benzoyl}amino)nicotinic acid | 6-[3-Isopropoxy-5-(2-thiophen-3-yl-ethoxy)-benzoylamino]-nicotinic acid | CHEMBL373339
Type:
Small organic molecule
Emp. Form.:
C22H22N2O5S
Mol. Mass.:
426.485
SMILES:
CC(C)Oc1cc(OCCc2ccsc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O
Structure:
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