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Target
Histone deacetylase 8
Ligand
BDBM50592728
Substrate
n/a
Meas. Tech.
ChEMBL_2204983 (CHEMBL5117691)
IC50
150±n/a nM
Citation
 Hauguel, C; Ducellier, S; Provot, O; Ibrahim, N; Lamaa, D; Balcerowiak, C; Letribot, B; Nascimento, M; Blanchard, V; Askenatzis, L; Levaique, H; Bignon, J; Baschieri, F; Bauvais, C; Bollot, G; Renko, D; Deroussent, A; Prost, B; Laisne, MC; Michallet, S; Lafanechère, L; Papot, S; Montagnac, G; Tran, C; Alami, M; Apcher, S; Hamze, A Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. Eur J Med Chem 240:0 (2022) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50592728
Synonyms:
CHEMBL5183440
Type:
Small organic molecule
Emp. Form.:
C21H18N4O3
Mol. Mass.:
374.3926
SMILES:
COc1ccc(cc1\C=C\C(=O)NO)N(C)c1cc(nc2ccccc12)C#N
Structure:
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