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Target
Cytochrome P450 2C6
Ligand
BDBM50592756
Substrate
n/a
Meas. Tech.
ChEMBL_2205318 (CHEMBL5118026)
Ki
203000±n/a nM
Citation
 Li, Y; Liu, Y; Chen, Y; Wang, K; Luan, Y Design, synthesis and antitumor activity study of a gemcitabine prodrug conjugated with a HDAC6 inhibitor. Bioorg Med Chem Lett 72:0 (2022) [PubMed]  Article
Target
Name:
Cytochrome P450 2C6
Synonyms:
1.14.14.1 | CP2C6_RAT | CYPIIC6 | Cyp2c-6 | Cyp2c6 | Cytochrome P450 PB1 | PTF2
Type:
PROTEIN
Mol. Mass.:
56009.77
Organism:
Rattus norvegicus
Description:
ChEMBL_104311
Residue:
490
Sequence:
MDLVMLLVLTLTCLILLSIWRQSSGRGKLPPGPIPLPIIGNIFQLNVKNITQSLTSFSKVYGPVFTLYFGTKPTVILHGYEAVKEALIDHGEEFAERGSFPVAEKINKDLGIVFSHGNRWKEIRRFTLTTLRNLGMGKRNIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICSIIFQNRFDYKDQDFLNLMEKLNENMKILSSPWTQFCSFFPVLIDYCPGSHTTLAKNVYHIRNYLLKKIKEHQESLDVTNPRDFIDYYLIKWKQENHNPHSEFTLENLSITVTDLFGAGTETTSTTLRYALLLLLKCPEVTAKVQEEIDRVVGKHRSPCMQDRSRMPYTDAHDHEVQRFIDLIPTNLPHAVTCDIKFRNYLIPKGTTIITSLSSVLHDSKEFPDPEIFDPGHFLDGNGKFKKSDYFMPFSAGKRMCAGEGLARMELFLFLTTILQNFKLKSVLHPKDIDTTPVFNGFASLPPFYELCFIPL
  
Inhibitor
Name:
BDBM50592756
Synonyms:
CHEMBL5182450
Type:
Small organic molecule
Emp. Form.:
C24H39F2N3O5
Mol. Mass.:
487.5804
SMILES:
CCCCCCCCCCCCCCC(=O)Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)c(=O)n1 |r|
Structure:
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