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Target
Dual specificity mitogen-activated protein kinase kinase 4
Ligand
BDBM50592884
Substrate
n/a
Meas. Tech.
ChEMBL_2205890 (CHEMBL5118598)
IC50
<1000±n/a nM
Citation
 Juchum, M; Pfaffenrot, B; Klövekorn, P; Selig, R; Albrecht, W; Zender, L; Laufer, SA Scaffold modified Vemurafenib analogues as highly selective mitogen activated protein kinase kinase 4 (MKK4) inhibitors. Eur J Med Chem 240:0 (2022) [PubMed]  Article
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 4
Synonyms:
JNK-activating kinase 1 | JNKK | JNKK1 | MAP kinase kinase 4 | MAP2K4 | MEK4 | MKK4 | MP2K4_HUMAN | PRKMK4 | SAPK/ERK kinase 1 | SEK1 | SERK1 | SKK1 | c-Jun N-terminal kinase kinase 1
Type:
PROTEIN
Mol. Mass.:
44294.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1460558
Residue:
399
Sequence:
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
  
Inhibitor
Name:
BDBM50592884
Synonyms:
CHEMBL3716507
Type:
Small organic molecule
Emp. Form.:
C17H12N4O
Mol. Mass.:
288.3034
SMILES:
NC(=O)c1ccc2[nH]c3ncnc(-c4ccccc4)c3c2c1
Structure:
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