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Target
Renin
Ligand
BDBM50165804
Substrate
n/a
Meas. Tech.
ChEMBL_304632 (CHEMBL828516)
IC50
35±n/a nM
Citation
 Powell, NA; Clay, EH; Holsworth, DD; Bryant, JW; Ryan, MJ; Jalaie, M; Zhang, E; Edmunds, JJ Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors. Bioorg Med Chem Lett 15:2371-4 (2005) [PubMed]  Article
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50165804
Synonyms:
(S)-6-[1-(3-Hydroxy-propyl)-1,2,3,4-tetrahydro-quinolin-7-yloxymethyl]-1-{4-[3-(2-methoxy-benzyloxy)-propoxy]-phenyl}-piperazin-2-one | CHEMBL445926
Type:
Small organic molecule
Emp. Form.:
C34H43N3O6
Mol. Mass.:
589.7217
SMILES:
COc1ccccc1COCCCOc1ccc(cc1)N1[C@H](COc2ccc3CCCN(CCCO)c3c2)CNCC1=O
Structure:
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