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Target
Ephrin type-B receptor 2
Ligand
BDBM50166045
Substrate
n/a
Meas. Tech.
ChEMBL_304919 (CHEMBL827811)
IC50
65000±n/a nM
Citation
 Toledo-Sherman, L; Deretey, E; Slon-Usakiewicz, JJ; Ng, W; Dai, JR; Foster, JE; Redden, PR; Uger, MD; Liao, LC; Pasternak, A; Reid, N Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening. J Med Chem 48:3221-30 (2005) [PubMed]  Article
Target
Name:
Ephrin type-B receptor 2
Synonyms:
DRT | Developmentally-regulated Eph-related tyrosine kinase | ELK-related tyrosine kinase | EPH tyrosine kinase 3 | EPH-like kinase 5 | EPHB2 | EPHB2_HUMAN | EPHT3 | EPTH3 | ERK | Ephrin receptor | HEK5 | TYRO5
Type:
PROTEIN
Mol. Mass.:
117491.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476221
Residue:
1055
Sequence:
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQSVEGQPLARRPRATGRTKRCQPRDVTKKTCNSNDGKKKGMGKKKTDPGRGREIQGIFFKEDSHKESNDCSCGG
  
Inhibitor
Name:
BDBM50166045
Synonyms:
3-(4-Chloro-phenyl)-1-[2-(5-fluoro-2-methyl-1H-indol-3-yl)-ethyl]-1-pyridin-4-ylmethyl-thiourea | CHEMBL191403
Type:
Small organic molecule
Emp. Form.:
C24H22ClFN4S
Mol. Mass.:
452.975
SMILES:
Cc1[nH]c2ccc(F)cc2c1CCN(Cc1ccncc1)C(=S)Nc1ccc(Cl)cc1
Structure:
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