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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50593045
Substrate
n/a
Meas. Tech.
ChEMBL_2206814 (CHEMBL5119522)
IC50
159±n/a nM
Citation
 Ito, T; Kinoshita, K; Tomizawa, M; Shinohara, S; Nishii, H; Matsushita, M; Hattori, K; Kohchi, Y; Kohchi, M; Hayase, T; Watanabe, F; Hasegawa, K; Tanaka, H; Kuramoto, S; Takanashi, K; Oikawa, N Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor. J Med Chem 65:12427-12444 (2022) [PubMed]  Article
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50593045
Synonyms:
CHEMBL5205778
Type:
Small organic molecule
Emp. Form.:
C28H21F3N2O5S
Mol. Mass.:
554.537
SMILES:
CC1(C)c2oc3cc(ccc3c2C(=O)c2ccc(NS(C)(=O)=O)cc12)C#Cc1cc(OCC(F)(F)F)ccn1
Structure:
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