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Target
Ribosomal protein S6 kinase beta-2
Ligand
BDBM50168242
Substrate
n/a
Meas. Tech.
ChEMBL_306115 (CHEMBL830066)
IC50
870.0±n/a nM
Citation
 Székelyhidi, Z; Pató, J; Wáczek, F; Bánhegyi, P; Hegymegi-Barakonyi, B; Erös, D; Mészáros, G; Hollósy, F; Hafenbradl, D; Obert, S; Klebl, B; Kéri, G; Orfi, L Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives. Bioorg Med Chem Lett 15:3241-6 (2005) [PubMed]  Article
Target
Name:
Ribosomal protein S6 kinase beta-2
Synonyms:
KS6B2_HUMAN | RPS6KB2 | Ribosomal protein S6 kinase (P70S6K) | STK14B
Type:
PROTEIN
Mol. Mass.:
53460.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_306115
Residue:
482
Sequence:
MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRAPVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRPGR
  
Inhibitor
Name:
BDBM50168242
Synonyms:
3-(5-{3-[5-(2-Carboxy-ethyl)-thiophen-2-yl]-benzo[g]quinoxalin-2-yl}-thiophen-2-yl)-propionic acid | CHEMBL366201
Type:
Small organic molecule
Emp. Form.:
C26H20N2O4S2
Mol. Mass.:
488.578
SMILES:
OC(=O)CCc1ccc(s1)-c1nc2cc3ccccc3cc2nc1-c1ccc(CCC(O)=O)s1
Structure:
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