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Target
Ribosomal protein S6 kinase alpha-5
Ligand
BDBM50168602
Substrate
n/a
Meas. Tech.
ChEMBL_304581 (CHEMBL828472)
IC50
>10000±n/a nM
Citation
 Bamford, MJ; Alberti, MJ; Bailey, N; Davies, S; Dean, DK; Gaiba, A; Garland, S; Harling, JD; Jung, DK; Panchal, TA; Parr, CA; Steadman, JG; Takle, AK; Townsend, JT; Wilson, DM; Witherington, J (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors. Bioorg Med Chem Lett 15:3402-6 (2005) [PubMed]  Article
Target
Name:
Ribosomal protein S6 kinase alpha-5
Synonyms:
90 kDa ribosomal protein S6 kinase 5 | KS6A5_HUMAN | MSK1 | Mitogen- and Stress-Activated Protein Kinase 1 (MSK1) | Nuclear mitogen- and stress-activated protein kinase 1 | Nuclear mitogen- and stress-activated protein kinase 1 (MSK1) | RPS6KA5 | RPS6KA5(Kin.Dom.2 - C-terminal) | RSK-like protein kinase | RSKL | Ribosomal protein S6 kinase | Ribosomal protein S6 kinase alpha 5 | Ribosomal protein S6 kinase alpha-5
Type:
Serine/threonine-protein kinase
Mol. Mass.:
89874.44
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
802
Sequence:
MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGYSFVAPSILFKRNAAVIDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPADSNNPETLFQFSDSVA
  
Inhibitor
Name:
BDBM50168602
Synonyms:
4-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-5-methyl-isoxazol-3-ylamine | CHEMBL188543
Type:
Small organic molecule
Emp. Form.:
C12H13N5O
Mol. Mass.:
243.2645
SMILES:
CCn1c(nc2cnccc12)-c1c(C)onc1N |(11.8,-8.55,;12.83,-7.41,;12.34,-5.96,;13.27,-4.7,;12.34,-3.45,;10.89,-3.93,;9.55,-3.16,;8.22,-3.93,;8.22,-5.48,;9.55,-6.24,;10.89,-5.48,;14.8,-4.58,;15.8,-5.75,;15.42,-7.24,;17.22,-5.17,;17.11,-3.64,;15.61,-3.26,;15.01,-1.85,)|
Structure:
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