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Target
Cyclin-dependent kinase 4
Ligand
BDBM50139171
Substrate
n/a
Meas. Tech.
ChEMBL_2218281 (CHEMBL5131615)
IC50
1.000000±n/a nM
Citation
 Raghuvanshi, R; Bharate, SB Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections. J Med Chem 65:893-921 (2022) [PubMed]  Article
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50139171
Synonyms:
Dinaciclib | MK-7965 | SCH-727965 | US11643396, Example Dinaciclib | US20230416221, Compound Dinaciclib
Type:
Small organic molecule
Emp. Form.:
C21H28N6O2
Mol. Mass.:
396.486
SMILES:
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(nc12)N1CCCC[C@H]1CCO |r|
Structure:
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