Reaction Details  Report a problem with these data
Target
Cysteinyl leukotriene receptor 2
Ligand
BDBM50596184
Substrate
n/a
Meas. Tech.
ChEMBL_2219706 (CHEMBL5133040)
IC50
>5000±n/a nM
Citation
 Fiorillo, B; Sepe, V; Conflitti, P; Roselli, R; Biagioli, M; Marchianò, S; De Luca, P; Baronissi, G; Rapacciuolo, P; Cassiano, C; Catalanotti, B; Zampella, A; Limongelli, V; Fiorucci, S Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem 64:16512-16529 (2021) [PubMed]  Article
Target
Name:
Cysteinyl leukotriene receptor 2
Synonyms:
CLTR2_HUMAN | CYSLT2 | CYSLT2R | CYSLTR2 | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39657.52
Organism:
Homo sapiens (Human)
Description:
Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75
Residue:
346
Sequence:
MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
  
Inhibitor
Name:
BDBM50596184
Synonyms:
CHEMBL5205127
Type:
Small organic molecule
Emp. Form.:
C36H38ClNO2S
Mol. Mass.:
584.21
SMILES:
[H][C@](CCc1ccccc1C(C)(C)C)(SCC1(CC(O)=O)CC1)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1 |r|
Structure:
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