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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50596229
Substrate
n/a
Meas. Tech.
ChEMBL_2219875 (CHEMBL5133209)
IC50
12±n/a nM
Citation
 Bender, AM; Carter, TR; Spock, M; Rodriguez, AL; Dickerson, JW; Rook, JM; Chang, S; Qi, A; Presley, CC; Engers, DW; Harp, JM; Bridges, TM; Niswender, CM; Conn, PJ; Lindsley, CW Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M Bioorg Med Chem Lett 56:0 (2022) [PubMed]  Article
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50596229
Synonyms:
CHEMBL5205163
Type:
Small organic molecule
Emp. Form.:
C25H32ClFN4
Mol. Mass.:
443
SMILES:
Fc1ccc(Cl)c(c1)-c1ccc(NC[C@@H]2CC22CCN(CC3CCCCC3)CC2)nn1 |r|
Structure:
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