Reaction Details  Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50044725
Substrate
n/a
Meas. Tech.
ChEMBL_2220293 (CHEMBL5133627)
Ki
204±n/a nM
Citation
 Dichiara, M; Artacho-Cordón, A; Turnaturi, R; Santos-Caballero, M; González-Cano, R; Pasquinucci, L; Barbaraci, C; Rodríguez-Gómez, I; Gómez-Guzmán, M; Marrazzo, A; Cobos, EJ; Amata, E Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation. Eur J Med Chem 230:0 (2022) [PubMed]  Article
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM50044725
Synonyms:
1-[2-(3,4-Dichloro-phenyl)-ethyl]-4-methyl-piperazine | CHEMBL73824
Type:
Small organic molecule
Emp. Form.:
C13H18Cl2N2
Mol. Mass.:
273.201
SMILES:
CN1CCN(CCc2ccc(Cl)c(Cl)c2)CC1
Structure:
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