Reaction Details  Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50596335
Substrate
n/a
Meas. Tech.
ChEMBL_2220293 (CHEMBL5133627)
Ki
933±n/a nM
Citation
 Dichiara, M; Artacho-Cordón, A; Turnaturi, R; Santos-Caballero, M; González-Cano, R; Pasquinucci, L; Barbaraci, C; Rodríguez-Gómez, I; Gómez-Guzmán, M; Marrazzo, A; Cobos, EJ; Amata, E Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation. Eur J Med Chem 230:0 (2022) [PubMed]  Article
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM50596335
Synonyms:
CHEMBL5198792
Type:
Small organic molecule
Emp. Form.:
C23H27ClN2O4
Mol. Mass.:
430.924
SMILES:
NC(=O)c1ccc(cc1)C(=O)OCCCCN1CCC(O)(CC1)c1ccc(Cl)cc1
Structure:
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