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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50173172
Substrate
n/a
Meas. Tech.
ChEMBL_321225 (CHEMBL880234)
IC50
116±n/a nM
Citation
 Graczyk, PP; Khan, A; Bhatia, GS; Palmer, V; Medland, D; Numata, H; Oinuma, H; Catchick, J; Dunne, A; Ellis, M; Smales, C; Whitfield, J; Neame, SJ; Shah, B; Wilton, D; Morgan, L; Patel, T; Chung, R; Desmond, H; Staddon, JM; Sato, N; Inoue, A The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold. Bioorg Med Chem Lett 15:4666-70 (2005) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50173172
Synonyms:
4-[(R)-2-(4-Fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-pyrimidin-2-ylamine | CHEMBL198427
Type:
Small organic molecule
Emp. Form.:
C25H24FN5O2
Mol. Mass.:
445.4888
SMILES:
COc1ccc(COC[C@H]2CCc3nc(c(-c4ccnc(N)n4)n23)-c2ccc(F)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: