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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM50597682
Substrate
n/a
Meas. Tech.
ChEMBL_2224123 (CHEMBL5137636)
IC50
4.0±n/a nM
Citation
 Xu, W; Kannan, S; Verma, CS; Nacro, K Update on the Development of MNK Inhibitors as Therapeutic Agents. J Med Chem 65:983-1007 (2022) [PubMed]  Article
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM50597682
Synonyms:
CHEMBL5206647
Type:
Small organic molecule
Emp. Form.:
C21H26N6OS
Mol. Mass.:
410.536
SMILES:
CN(C)CCCNC(=O)c1nc2c(ncnc2s1)N1CC(C)(C)c2ccccc12
Structure:
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