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Target
NT-3 growth factor receptor
Ligand
BDBM50598127
Substrate
n/a
Meas. Tech.
ChEMBL_2226252 (CHEMBL5139765)
IC50
12±n/a nM
Citation
 Wu, T; Qin, Q; Lv, R; Liu, N; Yin, W; Hao, C; Sun, Y; Zhang, C; Sun, Y; Zhao, D; Cheng, M Discovery of quinazoline derivatives CZw-124 as a pan-TRK inhibitor with potent anticancer effects in vitro and in vivo. Eur J Med Chem 238:0 (2022) [PubMed]  Article
Target
Name:
NT-3 growth factor receptor
Synonyms:
GP145-TrkC | NTRK3 | NTRK3_HUMAN | Neurotrophic tyrosine kinase receptor | Neurotrophic tyrosine kinase receptor type 3 | TRKC | Trk-C | TrkC tyrosine kinase | Tyrosine kinase receptor C (Trk-C)
Type:
Enzyme
Mol. Mass.:
94428.15
Organism:
Homo sapiens (Human)
Description:
Q16288
Residue:
839
Sequence:
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
  
Inhibitor
Name:
BDBM50598127
Synonyms:
CHEMBL5186552
Type:
Small organic molecule
Emp. Form.:
C20H18F2N6
Mol. Mass.:
380.3939
SMILES:
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3cc(C)ccc23)n[nH]1
Structure:
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