Reaction Details  Report a problem with these data
Target
Mitogen-activated protein kinase 14
Ligand
BDBM50175757
Substrate
n/a
Meas. Tech.
ChEMBL_328206 (CHEMBL863945)
IC50
3.2±n/a nM
Citation
 Bao, J; Hunt, JA; Miao, S; Rupprecht, KM; Stelmach, JE; Liu, L; Ruzek, RD; Sinclair, PJ; Pivnichny, JV; Hop, CE; Kumar, S; Zaller, DM; Shoop, WL; O'neill, EA; O'keefe, SJ; Thompson, CM; Cubbon, RM; Wang, R; Zhang, WX; Thompson, JE; Doherty, JB p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones. Bioorg Med Chem Lett 16:64-8 (2005) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50175757
Synonyms:
(2S)-2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydroquinolin-7-yl)piperidin-1-yl)propanoic acid | CHEMBL199565
Type:
Small organic molecule
Emp. Form.:
C29H24Cl3FN2O3
Mol. Mass.:
573.87
SMILES:
C[C@H](N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1)C(O)=O |wU:1.0,(22.43,-33.2,;22.43,-34.74,;21.1,-35.51,;21.1,-37.05,;19.77,-37.82,;18.43,-37.05,;18.42,-35.51,;19.76,-34.74,;17.1,-37.83,;17.1,-39.38,;15.76,-40.15,;15.77,-41.69,;14.43,-42.45,;14.43,-43.99,;15.76,-44.76,;15.76,-46.3,;17.1,-43.99,;17.1,-42.45,;18.43,-41.68,;14.43,-39.38,;13.1,-40.16,;11.76,-39.38,;11.76,-37.84,;10.43,-37.07,;13.1,-37.07,;13.1,-35.53,;11.77,-34.77,;10.44,-35.54,;11.77,-33.23,;13.11,-32.46,;14.44,-33.23,;14.44,-34.77,;15.77,-35.54,;14.43,-37.84,;15.76,-37.06,;23.76,-35.51,;25.1,-34.74,;23.76,-37.05,)|
Structure:
Search PDB for entries with ligand similarity: