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Target
cGMP-dependent protein kinase 1
Ligand
BDBM50598768
Substrate
n/a
Meas. Tech.
ChEMBL_2228070 (CHEMBL5141583)
EC50
9100±n/a nM
Citation
 Mak, VW; Patel, AM; Yen, R; Hanisak, J; Lim, YH; Bao, J; Zheng, R; Seganish, WM; Yu, Y; Healy, DR; Ogawa, A; Ren, Z; Soriano, A; Ermakov, GP; Beaumont, M; Metwally, E; Cheng, AC; Verras, A; Fischmann, T; Zebisch, M; Silvestre, HL; McEwan, PA; Barker, J; Rearden, P; Greshock, TJ Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1?. J Med Chem 65:10318-10340 (2022) [PubMed]  Article
Target
Name:
cGMP-dependent protein kinase 1
Synonyms:
GMP-dependent protein kinase I | KGP1_HUMAN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | Protein Kinase G | cGMP-dependent protein kinase | cGMP-dependent protein kinase 1 | cGMP-dependent protein kinase 1 beta
Type:
Protein
Mol. Mass.:
76358.04
Organism:
Homo sapiens (Human)
Description:
Q13976
Residue:
671
Sequence:
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF
  
Inhibitor
Name:
BDBM50598768
Synonyms:
CHEMBL5185417
Type:
Small organic molecule
Emp. Form.:
C28H28Cl2FNO3
Mol. Mass.:
516.431
SMILES:
Cc1cc(ccc1CN1CCC[C@H](O[C@H](CF)c2cc(Cl)cc(Cl)c2)[C@@H]1c1ccccc1)C(O)=O |r|
Structure:
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