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Target
Tryptophan 2,3-dioxygenase
Ligand
BDBM50599381
Substrate
n/a
Meas. Tech.
ChEMBL_2230345 (CHEMBL5144117)
IC50
51±n/a nM
Citation
 Kozlova, A; Thabault, L; Dauguet, N; Deskeuvre, M; Stroobant, V; Pilotte, L; Liberelle, M; Van den Eynde, B; Frédérick, R Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase. Eur J Med Chem 227:0 (2022) [PubMed]  Article
Target
Name:
Tryptophan 2,3-dioxygenase
Synonyms:
T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase
Type:
PROTEIN
Mol. Mass.:
47874.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_825691
Residue:
406
Sequence:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
  
Inhibitor
Name:
BDBM50599381
Synonyms:
CHEMBL5169552
Type:
Small organic molecule
Emp. Form.:
C14H9N3O
Mol. Mass.:
235.2408
SMILES:
c1[nH]c2ccccc2c1-c1ccc2nonc2c1
Structure:
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