Reaction Details 
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5-hydroxytryptamine receptor 2A
Ligand
BDBM50599912
Substrate
n/a
Meas. Tech.
ChEMBL_2232051 (CHEMBL5145823)
Ki
8300±n/a nM
Citation
Juza, R; Vojtechova, I; Stefkova-Mazochova, K; Dehaen, W; Petrasek, T; Prchal, L; Kobrlova, T; Janousek, J; Vlcek, P; Mezeiova, E; Svozil, D; Karasova, JZ; Pejchal, J; Stark, H; Satala, G; Bojarski, AJ; Kubacka, M; Mogilski, S; Randakova, A; Musilek, K; Soukup, O; Korabecny, J Novel D Eur J Med Chem 232:0 (2022) [PubMed] ArticleMore Info.:
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
Inhibitor
Name:
BDBM50599912
Synonyms:
CHEMBL5209381
Type:
Small organic molecule
Emp. Form.:
C26H34N6O2
Mol. Mass.:
462.5872
SMILES:
COc1ccccc1N1CCN(CCN2CCN(CC2)C(=O)c2nn(C)c3ccccc23)CC1
Structure:
