Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50179138
Substrate
n/a
Meas. Tech.
ChEMBL_335083 (CHEMBL859200)
EC50
14±n/a nM
Citation
Bakshi, RK; Hong, Q; Tang, R; Kalyani, RN; Macneil, T; Weinberg, DH; Van der Ploeg, LH; Patchett, AA; Nargund, RP Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands. Bioorg Med Chem Lett 16:1130-3 (2006) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Inhibitor
Name:
BDBM50179138
Synonyms:
CHEMBL380727 | ethyl (1-((R)-3-(4-chlorophenyl)-2-((R)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)propanoyl)-4-cyclohexylpiperidin-4-yl)methyl(isopropyl)carbamate
Type:
Small organic molecule
Emp. Form.:
C37H51ClN4O4
Mol. Mass.:
651.278
SMILES:
CCOC(=O)N(CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1)C(C)C