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Target
Melanocortin receptor 5
Ligand
BDBM50179138
Substrate
n/a
Meas. Tech.
ChEMBL_335087 (CHEMBL859204)
EC50
3600±n/a nM
Citation
 Bakshi, RK; Hong, Q; Tang, R; Kalyani, RN; Macneil, T; Weinberg, DH; Van der Ploeg, LH; Patchett, AA; Nargund, RP Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands. Bioorg Med Chem Lett 16:1130-3 (2006) [PubMed]  Article
Target
Name:
Melanocortin receptor 5
Synonyms:
MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36612.92
Organism:
Homo sapiens (Human)
Description:
P33032
Residue:
325
Sequence:
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
  
Inhibitor
Name:
BDBM50179138
Synonyms:
CHEMBL380727 | ethyl (1-((R)-3-(4-chlorophenyl)-2-((R)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)propanoyl)-4-cyclohexylpiperidin-4-yl)methyl(isopropyl)carbamate
Type:
Small organic molecule
Emp. Form.:
C37H51ClN4O4
Mol. Mass.:
651.278
SMILES:
CCOC(=O)N(CC1(CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)C1CCCCC1)C(C)C
Structure:
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