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Target
Serine/threonine-protein kinase Chk2
Ligand
BDBM50181266
Substrate
n/a
Meas. Tech.
ChEMBL_346016 (CHEMBL862313)
IC50
>10000±n/a nM
Citation
 McClure, KJ; Huang, L; Arienti, KL; Axe, FU; Brunmark, A; Blevitt, J; Breitenbucher, JG Novel non-benzimidazole chk2 kinase inhibitors. Bioorg Med Chem Lett 16:1924-8 (2006) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase Chk2
Synonyms:
CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2
Type:
Protein
Mol. Mass.:
60908.59
Organism:
Homo sapiens (Human)
Description:
O96017
Residue:
543
Sequence:
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
  
Inhibitor
Name:
BDBM50181266
Synonyms:
2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide | CHEMBL382588
Type:
Small organic molecule
Emp. Form.:
C19H14N4O2
Mol. Mass.:
330.3401
SMILES:
NC(=O)c1cnc2cc(nn2c1)-c1ccc(Oc2ccccc2)cc1
Structure:
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