Reaction Details 
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Adenosine receptor A3
Ligand
BDBM50602667
Substrate
n/a
Meas. Tech.
ChEMBL_2241750 (CHEMBL5155960)
EC50
35±n/a nM
Citation
Tosh, DK; Salmaso, V; Campbell, RG; Rao, H; Bitant, A; Pottie, E; Stove, CP; Liu, N; Gavrilova, O; Gao, ZG; Auchampach, JA; Jacobson, KA A Eur J Med Chem 228:0 (2022) [PubMed] ArticleMore Info.:
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
Inhibitor
Name:
BDBM50602667
Synonyms:
CHEMBL5196916
Type:
Small organic molecule
Emp. Form.:
C27H25ClN6O5S
Mol. Mass.:
581.043
SMILES:
CNC(=O)[C@@]12C[C@@H]1[C@H]([C@H](O)[C@@H]2O)n1cnc2c(NCc3ccc(O)c(OC)c3)nc(nc12)C#Cc1ccc(Cl)s1 |r|
Structure:
