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Target
Protein tyrosine phosphatase type IVA 3
Ligand
BDBM50184293
Substrate
n/a
Meas. Tech.
ChEMBL_365078 (CHEMBL871238)
IC50
1900±n/a nM
Citation
 Ahn, JH; Kim, SJ; Park, WS; Cho, SY; Ha, JD; Kim, SS; Kang, SK; Jeong, DG; Jung, SK; Lee, SH; Kim, HM; Park, SK; Lee, KH; Lee, CW; Ryu, SE; Choi, JK Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors. Bioorg Med Chem Lett 16:2996-9 (2006) [PubMed]  Article
Target
Name:
Protein tyrosine phosphatase type IVA 3
Synonyms:
PRL3 | PTP4A3 | Protein-tyrosine phosphatase 4A3 | TP4A3_HUMAN
Type:
PROTEIN
Mol. Mass.:
19546.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1461022
Residue:
173
Sequence:
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
  
Inhibitor
Name:
BDBM50184293
Synonyms:
5-[1-[3-(biphenyl-4-ylmethoxy)-naphthalen-2-yl]-methylidene]-2-thioxo-thiazolidin-4-one | CHEMBL378022
Type:
Small organic molecule
Emp. Form.:
C27H19NO2S2
Mol. Mass.:
453.575
SMILES:
SC1=NC(=O)C(S1)=Cc1cc2ccccc2cc1OCc1ccc(cc1)-c1ccccc1 |w:7.8,t:1|
Structure:
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