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Target
Sodium-dependent phosphate transport protein 2B
Ligand
BDBM50603229
Substrate
n/a
Meas. Tech.
ChEMBL_2243448 (CHEMBL5157658)
IC50
83±n/a nM
Citation
 Maemoto, M; Hirata, Y; Hosoe, S; Ouchi, J; Narushima, K; Akizawa, E; Tsuji, Y; Takada, H; Yanagisawa, A; Shuto, S Discovery of Gut-Restricted Small-Molecule Inhibitors of Intestinal Sodium-Dependent Phosphate Transport Protein 2b (NaPi2b) for the Treatment of Hyperphosphatemia. J Med Chem 65:1946-1960 (2022) [PubMed]  Article
Target
Name:
Sodium-dependent phosphate transport protein 2B
Synonyms:
NPT2B_HUMAN | Na(+)-dependent phosphate cotransporter 2B | Na(+)/Pi cotransporter 2B | NaPi-2b | NaPi3b | SLC34A2 | Sodium-phosphate transport protein 2B | Sodium/phosphate cotransporter 2B | Solute carrier family 34 member 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75771.66
Organism:
Homo sapiens (Human)
Description:
O95436
Residue:
690
Sequence:
MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL
  
Inhibitor
Name:
BDBM50603229
Synonyms:
CHEMBL5172873
Type:
Small organic molecule
Emp. Form.:
C39H50ClF3N4O9S
Mol. Mass.:
843.349
SMILES:
CC1(C)CCc2c(C1)sc(NC(=O)c1cccc(OCCOCCOCCOC[C@H](O)CN(CCO)CCO)c1)c2C(=O)N\N=C\c1ccc(Cl)c(c1)C(F)(F)F |r|
Structure:
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