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Target
Integrase
Ligand
BDBM50184677
Substrate
n/a
Meas. Tech.
ChEMBL_355753 (CHEMBL861104)
IC50
15±n/a nM
Citation
 Guare, JP; Wai, JS; Gomez, RP; Anthony, NJ; Jolly, SM; Cortes, AR; Vacca, JP; Felock, PJ; Stillmock, KA; Schleif, WA; Moyer, G; Gabryelski, LJ; Jin, L; Chen, IW; Hazuda, DJ; Young, SD A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors. Bioorg Med Chem Lett 16:2900-4 (2006) [PubMed]  Article
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50184677
Synonyms:
CHEMBL378029 | N-(4-fluorobenzyl)-8-hydroxy-5-(N-methyl-2-(methylamino)-2-oxoacetamido)-1,6-naphthyridine-7-carboxamide
Type:
Small organic molecule
Emp. Form.:
C20H18FN5O4
Mol. Mass.:
411.3864
SMILES:
CNC(=O)C(=O)N(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c2ncccc12
Structure:
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