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Target
Integrase
Ligand
BDBM50184681
Substrate
n/a
Meas. Tech.
ChEMBL_355753 (CHEMBL861104)
IC50
10±n/a nM
Citation
 Guare, JP; Wai, JS; Gomez, RP; Anthony, NJ; Jolly, SM; Cortes, AR; Vacca, JP; Felock, PJ; Stillmock, KA; Schleif, WA; Moyer, G; Gabryelski, LJ; Jin, L; Chen, IW; Hazuda, DJ; Young, SD A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors. Bioorg Med Chem Lett 16:2900-4 (2006) [PubMed]  Article
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50184681
Synonyms:
CHEMBL379658 | N-(4-fluorobenzyl)-5-(4-ethyl-2,3-dioxopiperazin-1-yl)-8-hydroxy-1,6-naphthyridine-7-carboxamide
Type:
Small organic molecule
Emp. Form.:
C22H20FN5O4
Mol. Mass.:
437.4237
SMILES:
CCN1CCN(C(=O)C1=O)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c2ncccc12
Structure:
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