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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50603809
Substrate
n/a
Meas. Tech.
ChEMBL_2245284 (CHEMBL5159494)
IC50
150±n/a nM
Citation
 Tomassi, S; Dimmito, MP; Cai, M; D'Aniello, A; Del Bene, A; Messere, A; Liu, Z; Zhu, T; Hruby, VJ; Stefanucci, A; Cosconati, S; Mollica, A; Di Maro, S CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists. J Med Chem 65:4007-4017 (2022) [PubMed]  Article
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R)
Type:
Enzyme
Mol. Mass.:
34717.23
Organism:
Homo sapiens (Human)
Description:
Q01726
Residue:
317
Sequence:
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
  
Inhibitor
Name:
BDBM50603809
Synonyms:
CHEMBL5188894
Type:
Small organic molecule
Emp. Form.:
C56H74N14O8S2
Mol. Mass.:
1135.406
SMILES:
CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CSCc2ccccc2CSC1(C)C)C(N)=O |r|
Structure:
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