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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50605028
Substrate
n/a
Meas. Tech.
ChEMBL_2249884 (CHEMBL5164094)
Ki
696±n/a nM
Citation
 Grychowska, K; Olejarz-Maciej, A; Blicharz, K; Pietru?, W; Karcz, T; Kurczab, R; Koczurkiewicz, P; Doroz-P?onka, A; Latacz, G; Keeri, AR; Piska, K; Sata?a, G; P?giel, J; Tryba?a, W; Jastrz?bska-Wi?sek, M; Bojarski, AJ; Lamaty, F; Partyka, A; Walczak, M; Krawczyk, M; Malikowska-Racia, N; Popik, P; Zajdel, P Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines. Eur J Med Chem 236:0 (2022) [PubMed]  Article
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50605028
Synonyms:
CHEMBL5197407
Type:
Small organic molecule
Emp. Form.:
C23H22ClN3O
Mol. Mass.:
391.893
SMILES:
Clc1cccc(Cn2ccc3c(NCC4CCCO4)nc4ccccc4c23)c1
Structure:
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