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Target
Melanocortin receptor 4
Ligand
BDBM50186862
Substrate
n/a
Meas. Tech.
ChEMBL_376512 (CHEMBL869042)
Ki
13±n/a nM
Citation
 Kuklish, SL; Backer, RT; Briner, K; Doecke, CW; Husain, S; Mullaney, JT; Ornstein, PL; Zgombick, JM; O'Brien, TP; Fisher, MJ Privileged structure based ligands for melanocortin receptors--4,4-disubstituted piperidine derivatives. Bioorg Med Chem Lett 16:3843-6 (2006) [PubMed]  Article
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50186862
Synonyms:
CHEMBL211260 | N-{(R)-1-(4-chloro-benzyl)-2-[4-(4-isobutyl-1-isopropyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-2-(2,3-dihydro-1H-isoindol-1-yl)-acetamide trifluoroaceticacid
Type:
Small organic molecule
Emp. Form.:
C35H50ClN5O2
Mol. Mass.:
608.257
SMILES:
CC(C)CC1(CCN(CC1)C(C)C)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12
Structure:
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