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Target
Cytochrome P450 4B1
Ligand
BDBM50607543
Substrate
n/a
Meas. Tech.
ChEMBL_2262943 (CHEMBL5217954)
IC50
>100000±n/a nM
Citation
 Barrows, RD; Jeffries, DE; Vishe, M; Tukachinsky, H; Zheng, SL; Li, F; Ma, Z; Li, X; Jin, S; Song, H; Zhang, R; Zhang, S; Ni, J; Luan, H; Wen, L; Rongshan, Y; Ying, C; Shair, MD Potent Uncompetitive Inhibitors of Nicotinamide  J Med Chem 65:14642-14654 (2022) [PubMed]  Article
Target
Name:
Cytochrome P450 4B1
Synonyms:
1.14.14.1 | CP4B1_HUMAN | CYP4B1 | CYPIVB1 | Cytochrome P450 4B1 | Cytochrome P450-HP
Type:
PROTEIN
Mol. Mass.:
59005.59
Organism:
Homo sapiens
Description:
ChEMBL_119703
Residue:
511
Sequence:
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
  
Inhibitor
Name:
BDBM50607543
Synonyms:
CHEMBL5220590
Type:
Small organic molecule
Emp. Form.:
C9H11N3O
Mol. Mass.:
177.2031
SMILES:
C[C@@H]1Cc2cc(cnc2N1)C(N)=O |r|
Structure:
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