Reaction Details  Report a problem with these data
Target
E3 ubiquitin-protein ligase RNF4
Ligand
BDBM50404381
Substrate
n/a
Meas. Tech.
ChEMBL_2264604
IC50
1800±n/a nM
Citation
 Yan, J; Li, T; Miao, Z; Wang, P; Sheng, C; Zhuang, C Homobivalent, Trivalent, and Covalent PROTACs: Emerging Strategies for Protein Degradation. J Med Chem 65:8798-8827 (2022) [PubMed]
Target
Name:
E3 ubiquitin-protein ligase RNF4
Synonyms:
2.3.2.27 | E3 ubiquitin-protein ligase RNF4 | Protein SNURF | RING finger protein 4 | RNF4 | Small nuclear ring finger protein
Type:
PROTEIN
Mol. Mass.:
21320.68
Organism:
Homo sapiens
Description:
ChEMBL_120971
Residue:
190
Sequence:
MSTRKRRGGAINSRQAQKRTREATSTPEISLEAEPIELVETAGDEIVDLTCESLEPVVVDLTHNDSVVIVDERRRPRRNARRLPQDHADSCVVSSDDEELSRDRDVYVTTHTPRNARDEGATGLRPSGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNANTCPTCRKKINHKRYHPIYI
  
Inhibitor
Name:
BDBM50404381
Synonyms:
CHEMBL5274740
Type:
Small organic molecule
Emp. Form.:
C22H20ClNO3
Mol. Mass.:
381.852
SMILES:
COc1ccc(Oc2ccc(cc2)N(Cc2ccccc2)C(=O)CCl)cc1
Structure:
Search PDB for entries with ligand similarity: