Reaction Details  Report a problem with these data
Target
Cyclin-dependent kinase 14
Ligand
BDBM50404389
Substrate
n/a
Meas. Tech.
ChEMBL_2264714
IC50
>1200±n/a nM
Citation
 Huang, Z; Wang, T; Wang, C; Fan, Y CDK9 inhibitors in cancer research. RSC Med Chem 13:688-710 (2022) [PubMed]
Target
Name:
Cyclin-dependent kinase 14
Synonyms:
CDK14 | CDK14_HUMAN | KIAA0834 | PFTK1 | Serine/threonine-protein kinase PFTAIRE-1
Type:
PROTEIN
Mol. Mass.:
53075.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774550
Residue:
469
Sequence:
MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
  
Inhibitor
Name:
BDBM50404389
Synonyms:
CHEMBL5285499
Type:
Small organic molecule
Emp. Form.:
C14H21N5
Mol. Mass.:
259.35
SMILES:
CCCc1cc(N[C@@H]2CC[C@@H](N)C2)n2nccc2n1 |r|
Structure:
Search PDB for entries with ligand similarity: