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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
Ligand
BDBM50405216
Substrate
n/a
Meas. Tech.
ChEMBL_2264882
IC50
2.0±n/a nM
Citation
 Padmakar Darne, C; Velaparthi, U; Saulnier, M; Frennesson, D; Liu, P; Huang, A; Tokarski, J; Fura, A; Spires, T; Newitt, J; Spires, VM; Obermeier, MT; Elzinga, PA; Gottardis, MM; Jayaraman, L; Vite, GD; Balog, A The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer. Bioorg Med Chem Lett 75:0 (2022) [PubMed]
Target
Name:
Steroid 17-alpha-hydroxylase/17,20 lyase
Synonyms:
17-alpha-hydroxyprogesterone aldolase | CP17A_MACFA | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450-C17 | Cytochrome P450c17 | Steroid 17-alpha-hydroxylase/17,20 lyase
Type:
PROTEIN
Mol. Mass.:
57634.34
Organism:
Macaca fascicularis
Description:
ChEMBL_116757
Residue:
508
Sequence:
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTLDILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQTIDISFPVFVAITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLFPWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGNPKVVFLIDSFKVKIKVRQAWREAQAEGST
  
Inhibitor
Name:
BDBM50405216
Synonyms:
CHEMBL5290029
Type:
Small organic molecule
Emp. Form.:
C16H11FN6
Mol. Mass.:
306.2971
SMILES:
Nc1ncncc1-c1ccnc2n(ncc12)-c1ccc(F)cc1
Structure:
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