Reaction Details Report a problem with these data
Target
Steroid 17-alpha-hydroxylase/17,20 lyase
Ligand
BDBM50405216
Substrate
n/a
Meas. Tech.
ChEMBL_2264888
IC50
2.0±n/a nM
Citation
Padmakar Darne, C; Velaparthi, U; Saulnier, M; Frennesson, D; Liu, P; Huang, A; Tokarski, J; Fura, A; Spires, T; Newitt, J; Spires, VM; Obermeier, MT; Elzinga, PA; Gottardis, MM; Jayaraman, L; Vite, GD; Balog, A The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer. Bioorg Med Chem Lett 75:0 (2022) [PubMed]
More Info.:
Target
Name:
Steroid 17-alpha-hydroxylase/17,20 lyase
Synonyms:
17-alpha-hydroxyprogesterone aldolase | CP17A_MACFA | CYP17 | CYP17A1 | CYPXVII | Cytochrome P450 17A1 | Cytochrome P450-C17 | Cytochrome P450c17 | Steroid 17-alpha-hydroxylase/17,20 lyase
Type:
PROTEIN
Mol. Mass.:
57634.34
Organism:
Macaca fascicularis
Description:
ChEMBL_116757
Residue:
508
Sequence:
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTLDILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQTIDISFPVFVAITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLFPWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGNPKVVFLIDSFKVKIKVRQAWREAQAEGST