Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50398057
Substrate
n/a
Meas. Tech.
ChEMBL_2265375
Ki
0.002500±n/a nM
Citation
 Fallica, ANCiaffaglione, VModica, MNPittalą, VSalerno, LAmata, EMarrazzo, ARomeo, GIntagliata, S Structure-activity relationships of mixed ? Bioorg Med Chem 73:0 (2022) [PubMed]
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50398057
Synonyms:
CHEMBL2181924
Type:
Small organic molecule
Emp. Form.:
C18H25FN2OS
Mol. Mass.:
336.467
SMILES:
FCCCc1ccc2n(CCN3CCCCCC3)c(=O)sc2c1
Structure:
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