Target
Nuclear receptor ROR-beta
Ligand
BDBM50406142
Substrate
n/a
Meas. Tech.
ChEMBL_2266266
IC50
>25000±n/a nM
Citation
 Schnute, METrujillo, JILee, KLUnwalla, RVajdos, FFKauppi, BNuhant, PFlick, ACCrouse, KKZhao, YSamuel, ALombardo, VTaylor, APBrault, ALKnafels, JDVazquez, MLBerstein, G Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists. ACS Med Chem Lett 14:191-198 (2023) [PubMed]
Target
Name:
Nuclear receptor ROR-beta
Synonyms:
NR1F2 | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB | RORB_HUMAN | RZRB | Retinoid-related orphan receptor-beta
Type:
PROTEIN
Mol. Mass.:
53227.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107979
Residue:
470
Sequence:
MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
  
Inhibitor
Name:
BDBM50406142
Synonyms:
CHEMBL5280788
Type:
Small organic molecule
Emp. Form.:
C21H33N3O3S
Mol. Mass.:
407.57
SMILES:
[H][C@]12CN(CCN1C(=O)C(C)C)Cc1cccc(NS(=O)(=O)CCCCC2)c1C |r|
Structure:
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