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Target
Sphingomyelinase C
Ligand
BDBM248061
Substrate
n/a
Meas. Tech.
ChEMBL_2266750
Ki
2800±n/a nM
Citation
 Skácel, J; Slusher, BS; Tsukamoto, T Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network. J Med Chem 64:279-297 (2021) [PubMed]
Target
Name:
Sphingomyelinase C
Synonyms:
PHL2_BACCE | Sphingomyelinase (SMase) | sph
Type:
Enzyme
Mol. Mass.:
36871.19
Organism:
Bacillus cereus
Description:
P11889
Residue:
333
Sequence:
MKGKLLKGVLSLGVGLGALYSGTSAQAEASTNQNDTLKVMTHNVYMLSTNLYPNWGQTERADLIGAADYIKNQDVVILNEVFDNSASDRLLGNLKKEYPNQTAVLGRSSGSEWDKTLGNYSSSTPEDGGVAIVSKWPIAEKIQYVFAKGCGPDNLSNKGFVYTKIKKNDRFVHVIGTHLQAEDSMCGKTSPASVRTNQLKEIQDFIKNKNIPNNEYVLIGGDMNVNKINAENNNDSEYASMFKTLNASVPSYTGHTATWDATTNSIAKYNFPDSPAEYLDYIIASKDHANPSYIENKVLQPKSPQWTVTSWFQKYTYNDYSDDYPVEATISMK
  
Inhibitor
Name:
BDBM248061
Synonyms:
SMY-471
Type:
Small organic molecule
Emp. Form.:
C29H45N3O2
Mol. Mass.:
467.6865
SMILES:
CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COCc1cccc(n1)-c1ccccn1 |r|
Structure:
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