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Target
Prothrombin
Ligand
BDBM50193225
Substrate
n/a
Meas. Tech.
ChEMBL_381888 (CHEMBL870372)
IC50
>300000±n/a nM
Citation
 De Nanteuil, G; Gloanec, P; Béguin, S; Giesen, PL; Hemker, HC; Mennecier, P; Rupin, A; Verbeuren, TJ Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders. J Med Chem 49:5047-50 (2006) [PubMed]  Article
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50193225
Synonyms:
CHEMBL424882 | {(R)-1-[6-(4-carbamimidoyl-benzylcarbamoyl)-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-6-ylcarbamoyl]-2-methyl-propylamino}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C31H35N5O4
Mol. Mass.:
541.6407
SMILES:
CC(C)[C@@H](NCC(O)=O)C(=O)NC1(Cc2ccccc2-c2ccccc2C1)C(=O)NCc1ccc(cc1)C(N)=N
Structure:
Search PDB for entries with ligand similarity: