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Target
Platelet-activating factor acetylhydrolase
Ligand
BDBM50193715
Substrate
n/a
Meas. Tech.
ChEMBL_424056 (CHEMBL855065)
IC50
120±n/a nM
Citation
 Jeong, HJ; Park, YD; Park, HY; Jeong, IY; Jeong, TS; Lee, WS Potent inhibitors of lipoprotein-associated phospholipase A(2): benzaldehyde O-heterocycle-4-carbonyloxime. Bioorg Med Chem Lett 16:5576-9 (2006) [PubMed]  Article
Target
Name:
Platelet-activating factor acetylhydrolase
Synonyms:
1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase
Type:
PROTEIN
Mol. Mass.:
50084.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_156212
Residue:
441
Sequence:
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
  
Inhibitor
Name:
BDBM50193715
Synonyms:
(2Z)-{[(morpholin-4-ylcarbonyl)oxy]imino}(phenyl)acetonitrile | CHEMBL373696
Type:
Small organic molecule
Emp. Form.:
C13H13N3O3
Mol. Mass.:
259.2606
SMILES:
O=C(O\N=C(/C#N)c1ccccc1)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: