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Target
Estrogen receptor
Ligand
BDBM50194088
Substrate
n/a
Meas. Tech.
ChEMBL_402354 (CHEMBL867419)
IC50
260±n/a nM
Citation
 Kinzel, O; Fattori, D; Muraglia, E; Gallinari, P; Nardi, MC; Paolini, C; Roscilli, G; Toniatti, C; Gonzalez Paz, O; Laufer, R; Lahm, A; Tramontano, A; Cortese, R; De Francesco, R; Ciliberto, G; Koch, U A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies. J Med Chem 49:5404-7 (2006) [PubMed]  Article
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM50194088
Synonyms:
9a-benzyl-4-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one | CHEMBL385514
Type:
Small organic molecule
Emp. Form.:
C24H26O2
Mol. Mass.:
346.462
SMILES:
CCCCC1=C2c3ccc(O)cc3CC2(Cc2ccccc2)CCC1=O |c:4|
Structure:
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