Reaction Details  Report a problem with these data
Target
DNA oxidative demethylase ALKBH2
Ligand
BDBM50361471
Substrate
n/a
Meas. Tech.
ChEMBL_2269245
IC50
424000±n/a nM
Citation
 Perry, GS; Das, M; Woon, ECY Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets. J Med Chem 64:16974-17003 (2021) [PubMed]
Target
Name:
DNA oxidative demethylase ALKBH2
Synonyms:
1.14.11.33 | ABH2 | ALKB2_HUMAN | ALKBH2 | Alkylated DNA repair protein alkB homolog 2 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 | Oxy DC1
Type:
PROTEIN
Mol. Mass.:
29338.68
Organism:
Homo sapiens
Description:
ChEMBL_120703
Residue:
261
Sequence:
MDRFLVKGAQGGLLRKQEEQEPTGEEPAVLGGDKESTRKRPRREAPGNGGHSAGPSWRHIRAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSGVTGQTFNFVLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDSRGKSPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRKILLTKK
  
Inhibitor
Name:
BDBM50361471
Synonyms:
CHEMBL1614745
Type:
Small organic molecule
Emp. Form.:
C5H8O5
Mol. Mass.:
148.114
SMILES:
O[C@H](CCC(O)=O)C(O)=O |r|
Structure:
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