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Target
DNA oxidative demethylase ALKBH2
Ligand
BDBM50596053
Substrate
n/a
Meas. Tech.
ChEMBL_2269249
IC50
25900±n/a nM
Citation
 Perry, GS; Das, M; Woon, ECY Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets. J Med Chem 64:16974-17003 (2021) [PubMed]
Target
Name:
DNA oxidative demethylase ALKBH2
Synonyms:
1.14.11.33 | ABH2 | ALKB2_HUMAN | ALKBH2 | Alkylated DNA repair protein alkB homolog 2 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 | Oxy DC1
Type:
PROTEIN
Mol. Mass.:
29338.68
Organism:
Homo sapiens
Description:
ChEMBL_120703
Residue:
261
Sequence:
MDRFLVKGAQGGLLRKQEEQEPTGEEPAVLGGDKESTRKRPRREAPGNGGHSAGPSWRHIRAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSGVTGQTFNFVLINRYKDGCDHIGEHRDDERELAPGSPIASVSFGACRDFVFRHKDSRGKSPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRKILLTKK
  
Inhibitor
Name:
BDBM50596053
Synonyms:
CHEMBL5173876
Type:
Small organic molecule
Emp. Form.:
C17H15N3O4
Mol. Mass.:
325.3187
SMILES:
OC(=O)\C=C\C(=O)NNC(=O)c1cnccc1Cc1ccccc1
Structure:
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