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Target
Alpha-ketoglutarate-dependent dioxygenase FTO
Ligand
BDBM50344962
Substrate
n/a
Meas. Tech.
ChEMBL_2269253
IC50
>1000000±n/a nM
Citation
 Perry, GS; Das, M; Woon, ECY Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets. J Med Chem 64:16974-17003 (2021) [PubMed]
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase FTO
Synonyms:
FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752
Type:
PROTEIN
Mol. Mass.:
58263.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515854
Residue:
505
Sequence:
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP
  
Inhibitor
Name:
BDBM50344962
Synonyms:
(2S)-2-HYDROXYPENTANEDIOIC ACID | CHEMBL1615211 | L-2-Hydroxyglutarate
Type:
Small organic molecule
Emp. Form.:
C5H8O5
Mol. Mass.:
148.114
SMILES:
O[C@@H](CCC(O)=O)C(O)=O |r|
Structure:
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