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Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM50295341
Substrate
n/a
Meas. Tech.
ChEMBL_2271378
IC50
570±n/a nM
Citation
 Rana, P; Ghouse, SM; Akunuri, R; Madhavi, YV; Chopra, S; Nanduri, S FabI (enoyl acyl carrier protein reductase) - A potential broad spectrum therapeutic target and its inhibitors. Eur J Med Chem 208:0 (2020) [PubMed]
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-ACP Reductase (InhA) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-[acyl-carrier-protein] reductase [NADH] | INHA_MYCTU | NADH-dependent enoyl-ACP reductase | inhA
Type:
Enzyme
Mol. Mass.:
28526.00
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
P9WGR1
Residue:
269
Sequence:
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL
  
Inhibitor
Name:
BDBM50295341
Synonyms:
CHEMBL3597020
Type:
Small organic molecule
Emp. Form.:
C20H25NO2
Mol. Mass.:
311.418
SMILES:
CC1(C)CCC(Cc2cc(O)c(-c3ccccc3)c(=O)[nH]2)CC1
Structure:
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